What is SALL4 ?
SALL4 is an oncofetal protein essential for early development and later causes cancer.
A key stem cell factor, SALL4 has well-known functions in embryonic and fetal development of various organs such as brain and limbs
Key Function
A tumor driver, not merely a tumor marker. SALL4 transgenic mice develop liver and blood cancers; SALL4 knockout resistant to tumor formation
Mechanism
Transcription factor with 4 zinc finger domains and 2 major protein isoforms
Structure
Given the labs’ world renowned expertise in SALL4 and oncoprotein research, we are uniquely positioned to lead the effort in therapeutic targeting.
SALL4 PEPTIDE INHIBITOR SHOWS UNPRECEDENTED INHIBITION OF TUMOR GROWTH IN HCC MODEL
BPY-1: Therapeutic peptide inhibitor with high potency
High Potency : 23 nanoMolar IC50
Small molecular weight : 10 amino acids core strucutre
Nuclear envelope permeability: Linked to a cell/nuclear penetration sequence
Excellent target affinity: Covers the shallow binding pocket between RBBP4 (chaperone subunit of NuRD) And SALL4
